Science is Fun Fridays!
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We started talking about snakes yesterday so this felt right. This seemingly friendly face belongs to one of the most venomous snakes in the world - the black mamba. A team has produced a single antivenom that provided mice with full protection against 13 species, and partial protection against six other species. They are confident they are within reach of an antivenom that covers all snakes that use neurotoxic venom, which includes cobras, taipans, black mambas, and some sea snakes. This is partly in thanks to Tim Friede, a snake handler and collector. He started with injections of venom, small dilutions, before taking it straight from the snake's mouth. He developed hyperimmunity and had more specific antibodies directed towards snake venom than most/any human. Centivax reached out to him so that they could study these antibodies. They identified certain common features from the different snake toxins and antibodies, such as LNX-D09 which blocks the activity of many ...