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 Chronic pain conditions occur more often in US adults than other prevalent conditions like diabetes and depression.  About 1 in 5 adults live with chronic pain. Scientists have recently developed a synthetic cannabinoid that keeps the pain-relieving properties of cannabis without being psychoactive - or addictive, like pharmaceutical opioids. The team designed a molecule that is positively charged, which prevents it from being able to cross the blood-brain barrier.  This means it cannot bind to its target cannabinoid receptor (CB1) in the brain, but can act on cells in the rest of the body. Studies on the compound, known as VIP36, shows the effect persists without showing signs of tolerance. This is the kind of important research NIH grants help support. Helping to End Addiction Long-Term Initiative

 First up, we checked out Kyle Hot Springs. Somebody built an awesome tub here. Next, Hubby wanted to see if Wall Canyon was frozen over. And we stayed for the night. Bowie likes to look out on the water, whereas Mighty is waiting for fish.

  It's not his birthday or any other milestone, but it is Hitchcock Day. Known as the "Master of Suspense," he literally helped shape the thriller genre. Blackmail  from 1929 was the first British film to feature synchronized sound. Psycho  is a horror classic, and was presented to be as much even as it premiered.  The marketing of fear was a brilliant approach. And the score is one of the most haunting tracks ever used to this day.

 I've had kind of a slow start with this, nothing against the book.  It's actually kind of interesting how it's written.  When the worst things happen, it's not really detailed.  You're left with the sense of what happened, and knowing, historically, that it's bad. And you know that Elwood shouldn't even be here.... My goal is to finish this month, so that way I'm all clear for Shakespeare in April. I'm leaning towards Othello  this year. What have you been reading or planning to read?

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  From The Big Lebowski , released on this day in 1998, a sort of religion has been born. It's called "Dudeism," and is a kind of modern form of Taoism. A philosophy to take it easy and embrace simplicity, promoting a relaxed lifestyle. I'd like to add one: "This aggression will not stand, man." So yeah, a chill open thread as we'll be going camping tomorrow.  😎

 And some hump day history. Starting with Johnny Cash, who had enlisted in 1950 and was assigned to the 124th Radio Squadron Mobile of the US Air Force Security Service in West Germany.  As Air Force Staff Sergeant, he intercepted a coded message on this day in 1953, and America learned of Stalin's death. In 1954, Cash moved to Nashville and was playing music with the The Tennessee Two.  By 1955, he was able to get his first recordings at Sun Records. Also on this day and connected to Nashville, the death of Patsy Cline in 1963.  Along with Cowboy Copas and Hawkshaw Hawkins, their plane crashed near Camden following a benefit concert. (Kansas City disc jockey "Cactus" Jack Call had died in a car accident, the concert was for his widow.  And then, en route to Cline's funeral, country singer Jack Anglin died in a car crash). Cline was the first country singer to cross over as a pop artist. In 1960, Cline was injured in a car accident.  After recovery, she rec...

Jackie and Shadow have returned to Big Bear Valley and have three eggs in their nest. As of last night, one is hatching and a second is showing some cracks.  The third is still early. This is their first eaglet since 2022.

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  Neutrinos are subatomic particles that are very small, neutral, and have almost no mass.  They are called "ghost particles" because they rarely interact with other matter. But recently, a cosmic neutrino plunged into the Mediterranean Sea with an energy that blows all other neutrinos out of the water. With some 220 million billion electron volts, this particle was around 20 times as energetic as the highest seen before. It was seen thanks to the partially built Cubic Kilometre Neutrino Telescope located at the bottom of the sea. The neutrino detectors are three-dimensional arrays of light sensor modules or optical modules distributed over large volumes of the transparent water.  The optical modules register the faint Cherenkov light from charged particles induced by neutrino interactions in the seawater. There's more. The neutrino's interaction with matter spawns charged particles such as muons.  As these careen through the water, that is what the detectors pick up...